As discussed in other articles in the database, the use of antacids seem to only impair protein bound vitamin B12 ingested from animal derived dietary sources. About Us Disclaimer Contact Us. Toggle navigation. Please enter text to search. Search by Outlines. Set Search Limits. Medications Known to Decrease Vitamin B12 Levels Summary : As summarized in the table provided, vitamin B12 cobalamin absorption and utilization by the body can be compromised with the chronic use of certain medications which include: colchicine, chloramphenicol, ethanol, histamine 2 receptor antagonists H2RA , metformin, and proton pump inhibitors PPI.
Editor-in-Chief: Anthony J. Explanation It is now known that some medications, when used chronically, can result in undesirable side effects that were not necessarily obvious or present within most initial clinical trials. Office of Dietary Supplements. Accessed Jan. Fairfield KM.
Vitamin supplementation in disease prevention. Means RT Jr, et al. Causes and pathophysiology of vitamin B12 and folate deficiencies. IBM Micromedex. Natural Medicines. Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Legal Conditions and Terms Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Advertising Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission.
Advertising and sponsorship policy Advertising and sponsorship opportunities. Vitamin B12 requires acid in the stomach and a protein called intrinsic factor to be absorbed adequately. Alcohol can ultimately alter how vitamin B12 is absorbed.
Studies have shown that over 8 weeks of moderate alcohol consumption, vitamin B12 levels can decrease over time. H2 blockers are sometimes referred to as H2 antagonists and include drugs like Zantac ranitidine and Pepcid famotidine.
These drugs are used to treat heartburn and stomach ulcers by decreasing acid production in the stomach. A decrease in stomach acid can lead to decreased absorption of vitamin B Proton pump inhibitors, also known as PPIs, include drugs like Prilosec omeprazole and Prevacid lansoprazole.
Because they primarily work by decreasing stomach acid production, these drugs can decrease the absorption of vitamin B12 in the body. Dilantin Phenytoin , Tegretol carbamazepine , and Depakote valproate are anticonvulsants, or medications used to treat seizures.
These drugs may affect the metabolism, or the processing, of vitamin B12 in the body. Studies have shown that anticonvulsant drugs can decrease folate and vitamin B12 levels in the body. Bile acid sequestrants are cholesterol-lowering drugs. They work by absorbing cholesterol molecules in the intestine and promoting the elimination of bile acids in the stool.
Bile acid sequestrants include Questran cholestyramine and Colestid colestipol , and they may interfere with the absorption of calcium, folate, iron, and vitamins, including vitamin B Taking bile acid sequestrants with vitamin B12 supplements may lead to a decrease in vitamin B12 in the body, which could increase the risk of vitamin B12 deficiency. Advanced Study. Related Information. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.
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